文章摘要
张海燕,罗万慰,马守梅,许联红.细胞色素P450酶4F2基因多态性对华法林剂量影响的研究[J].药学与临床研究,2010,18(4):338~340
细胞色素P450酶4F2基因多态性对华法林剂量影响的研究
Association of CYP4F2 Gene Polymorphism with Warfarin Dose
投稿时间:2010-04-10  修订日期:2010-06-03
DOI:
中文关键词: 细胞色素P450酶4F2  华法林  基因多态性
英文关键词: CYP4F2  Warfarin  Polymorphism
基金项目:
作者单位
张海燕 江苏大学附属武进医院药剂科常州 213002 
罗万慰 江苏大学附属武进医院药剂科常州 213002 
马守梅 江苏大学附属武进医院心胸外科常州 213002 
许联红 江苏大学附属武进医院中心实验室常州 213002 
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中文摘要:
      目的:探讨中国苏南地区心脏机械瓣膜置换术后汉族人群细胞色素P450酶4F2(CYP4F2)基因rs2108622多态性对华法林剂量的影响,为以后利用基因多态性指导临床合理用药提供进一步理论依据。方法:采用碱基淬灭探针技术,检测197名心脏机械瓣膜置换术后患者的CYP4F2 rs2108622的基因型,分析与华法林剂量的相关性及影响。结果:CYP4F2 rs2108622基因多态性检测有115例CC型纯合子,73例CT型杂合子,9例TT型突变纯合子;等位基因频率为C 76.9%,T 23.1%;CC型患者华法林的平均稳定剂量为(2.51±0.82)mg·d-1,CT型为(2.74±0.96)mg·d-1,TT型为(3.20±1.22)mg·d-1,采用方差分析方法得到各组间华法林剂量差异P值小于0.05,有显著性差异。结论:在苏南地区心脏机械瓣膜置换术后汉族人群中,CYP4F2 rs2108622基因多态性与华法林剂量相关性有显著性差异,对华法林剂量有影响。
英文摘要:
      Objective: To investigate the association of CYP4F2 rs2108622 polymorphism with warfarin maintenance dose in the Han population of the south of Jiangsu province of Chinese. Methods: The single nucleotide polymorphism was detected by using a base-quenched probe technique. CYP4F2 rs2108622 polymorphisms were analyzed in 197 patients with mechanical heart valve replacement. Results: The genotypes of CYP4F2 rs2108622 showed that 115 patients were homozygous CC, 73 were heterozygous CT, and 9 were homozygous TT genotype. The allelic frequency was C 76.9% and T 23.1%, respectively. The required warfarin dose for patients with the CYP4F2 rs2108622 genotype was CC (2.51±0.82) mg·d-1, CT (2.74±0.96) mg·d-1,and TT (3.20±1.22) mg·d-1, respectively. Analysis of variance showed CYP4F2 rs2108622 was associated with warfarin dose. Conclusion: Our data shows that CYP4F2 rs2108622 is associated with the dose of warfarin in the Han population of the south of Jiangsu province.
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