文章摘要
刘桂良,王继红,王 涛.唇腭裂手术期预防性应用抗生素必要性的探讨[J].药学与临床研究,2010,18(4):381~382
唇腭裂手术期预防性应用抗生素必要性的探讨
A Study on the Necessority of Pre-operational Antibiotic Prophylaxis in Cleft Lip and Palate Patients
投稿时间:2010-04-16  修订日期:2010-05-05
DOI:
中文关键词: 唇腭裂  抗生素  预防性应用
英文关键词: Cleft lip and palate  Antibiotic  Prophylaxis
基金项目:
作者单位
刘桂良 江苏省南京市南京医科大学附属口腔医院药剂科南京 210029 
王继红 江苏省南京市南京医科大学附属口腔医院药剂科南京 210029 
王 涛 江苏省南京市南京医科大学附属口腔医院颌面外科南京 210029 
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中文摘要:
      目的:探讨唇腭裂患者术前预防性应用抗生素的必要性。方法:实验组术前30min-1h肌注/静脉滴注注射用头孢唑啉钠,对照组围手术期不给药,术后常规用药,参照国家卫生部医政司医院感染研究组制定的标准评价切口感染情况。结果:实验组和对照组术后一般情况基本一致。实验组和对照组抗生素使用时间及费用存在显著差异(P<0.05),切口愈合情况存在显著差异(P<0.05)。结论:唇腭裂术前预防性应用抗生素能有效预防感染,且能减少用药费用。
英文摘要:
      Objective: To study the necessity of antibiotic prophylaxis in cleft lip and palate patients. Methods: Patients in experimental group were given cefazolin sodium in 30-60 min before operation, and patients in control group used antibiotic after operation as usual without having any antibiotic before operation. Surgical wounds were judged referring to the standards made by the Hospital Infection Research Group of the Ministry of Health of the People′s Republic of China. Result: Experimental group and control group had no difference in general condition, but had significant differences in the time and expense of antibiotic usage (P<0.05), as well as in wound healing (P<0.05). Conclusion: Antibiotic prophylaxis before operation could prevent bacteria infection, and could lessen the expense of antibiotics.
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