文章摘要
顾芬芬,胡楚玲,台宗光,高申,陈中建.前列腺癌新型靶向纳米超声造影剂的合成及初步评价[J].药学与临床研究,2018,26(4):257~260
前列腺癌新型靶向纳米超声造影剂的合成及初步评价
Preparation of a Novel Nano Ultrasound Contrast Agent Targeting at Prostate Cancer
投稿时间:2018-03-26  修订日期:2018-04-27
DOI:
中文关键词: 多壁碳纳米管  适体  纳米靶向造影剂  前列腺癌
英文关键词: Multi-walled carbon nanotubes  Aptamer  Targeted nano contrast agent  Prostate cancer
基金项目:
作者单位E-mail
顾芬芬 上海交通大学医学院附属新华医院 药学部 fenfen09@163.com 
胡楚玲 海军军医大学附属长海医院 药学部  
台宗光 海军军医大学附属长海医院 药学部  
高申 海军军医大学附属长海医院 药学部  
陈中建 上海中医药大学附属皮肤病性病医院 药学部
上海中医药大学附属皮肤病性病医院 药学部 
 
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中文摘要:
      目的:研究制备一种前列腺癌新型靶向性纳米超声造影剂。方法:采用PEG及抗前列腺癌特异性膜抗原(PSMA)适体A10-3.2修饰多壁碳纳米管(MWCNTs)合成新型靶向纳米超声造影剂,对其进行合成验证、体外特征评价、生物相容性研究及体外显影评价。结果:Zeta电位、透射电镜扫描图(TEM)、红外分析图(FT-IR)均表明此靶向纳米造影剂合成成功。体外细胞学研究表明,该造影剂细胞毒性小、生物相容性好。体外显影结果表明,该造影剂具有良好的显影效果。结论:该新型造影剂制备成功,具备靶向显影的潜能。
英文摘要:
      Objective: To prepare a prostate cancer targeted nano-ultrasound contrast agent. Methohs: Multi-walled carbon nanotubes (MWCNTs) were modified by PEG and anti-PSMA aptamers, and the resulted products were researched on their characteristics, biological compatibility as well as development in vitro. Results: Zeta potential, transmission electron microscopy (TEM) and infrared analysis (FT-IR) results showed that this targeted nano contrast agent had been successfully synthesized. In vitro cytology showed that the contrast agent had good biocompatibility. The contrast agent had good development effects outside the body. Conclusion: The novel contrast agent has been prepared sucessfully with the potential for prostate cancer targeting development.
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