文章摘要
徐航,王璐,王宝彦,李丹滢,雷署丰.纤溶酶原激活物抑制剂-1启动子基因多态性与静脉血栓栓塞症的相关性研究[J].药学与临床研究,2018,26(4):261~264
纤溶酶原激活物抑制剂-1启动子基因多态性与静脉血栓栓塞症的相关性研究
Relationship between the Promoter Polymorphism of Plasminogen Activator Inhibitor-1 and Venous Thromboembolism
投稿时间:2018-06-11  修订日期:2018-08-09
DOI:
中文关键词: 静脉血栓栓塞  纤溶酶原激活物抑制剂-1  基因多态性
英文关键词: Venous thrombosis  Plasminogen activator inhibitor-1  Polymorphism
基金项目:南京市医学科技发展资金资助(QRX17060);江苏省药学会-Shire生物药学基金(S201606)
作者单位E-mail
徐航 苏州大学医学部公共卫生学院 xiaochongzi78@sina.com 
王璐 中国药科大学基础医学与临床药学学院  
王宝彦 南京大学医学院附属鼓楼医院药学部  
李丹滢 南京大学医学院附属鼓楼医院药学部  
雷署丰 苏州大学医学部公共卫生学院 leisf@suda.edu.cn 
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中文摘要:
      目的:探讨中国汉族人群纤溶酶原激活物抑制剂PAI-1启动子4G/5G基因多态性与静脉血栓栓塞症(VTE)发病的相关性。方法:采用病例-对照研究,收集南京鼓楼医院2016年1月~2018年3月VTE患者160例及正常人群160例,应用聚合酶链反应测定PAI-1启动子区域的4G/5G的多态性。结果:PAI-1基因4G/5G三种基因型4G/4G型、4G/5G型、5G/5G型在VTE组的分布频率为42.50%、35.00%、22.50%,对照组分布频率为17.50%、43.12%、39.38%,VTE组与对照组4G/4G基因型分布差异具有统计学意义(P<0.05);通过非条件Logistic回归模型校正后,PAI-1 4G/4G基因型(OR=3.398,95% CI=2.025~5.702,P=0.000)、吸烟(OR=1.447,95% CI=1.022~2.049,P=0.037)是VTE的独立危险因素。结论:VTE组PAI-1 4G/4G基因型频率较正常人群高,证实了4G/4G基因型与静脉血栓栓塞发病有相关性,且为独立危险因素。
英文摘要:
      Objective: In this study, the distribution of genotypes and frequency of alleles of the 4G/5G polymorphism of PAI-1 gene in Chinese patients with venous thrombosis were investigated for their roles in development of venous thromboembolism. Methods: A case-control study was conducted in the Nanjing Drum Tower Hospital. A total of 160 VTE patients and 160 healthy controls were studied for the PAI-1 4G/5G polymorphism by allele-specific PCR from January 2016 to March 2018. Results: The frequency distribution of 4G/4G, 4G/5G and 5G/5G genotypes were 42.50%, 35.00% and 22.50% in the VTE group, and 17.50%, 43.12% and 39.38% in the control group, respectively. The difference of PAI-1 4G/4G genotype distribution between the VTE group and the control group was statistically significant (P<0.05); Corrected by unconditional logistic regression model, 4G/4G was associated with VTE risk(OR=3.398,95% CI=2.025~5.702,P=0.000)and smoking(OR=1.447,95% CI=1.022~2.049, P=0.037)was an independent risk factor for VTE. Conclusions: PAI-1 4G/4G is an independent strong risk factor for venous thrombosis in Chinese patients and should be included in laboratory testing panel of thrombophilia.
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